Major Shareholders

Shareholders with interests of over 3% (Significant Shareholders), as advised to the Company, are listed to the right.

In so far as the Company is aware, the percentage of the Company’s issued share capital that is not in public hands is 2.6%, which comprises the  directors’ beneficial holdings of 2.6%.

Name of shareholder Number of ordinary shares % of share capital

Polar Capital LLP

8,264,047 5.0%

Tikvah Management LLC

8,045,000

4.9%

Venrock Healthcare Capital Partners (II and III)

7,655,000

4.6%

Leonard Licht 7,375,000 4.5%