Application of cell models of disease
Advanced human tissue models of respiratory disease have been developed in collaboration with the University of Southampton. Synairgen has established in vitro tissue engineering platforms and the 'know-how' to utilise Biobank-derived clinical samples for development of complex in vitro human cell models for multiple applications.
In vitro models:
- Primary bronchial epithelial cell cultures
- Primary bronchial fibroblast cultures
- Co-cultures
- Explant cultures
Ex vivo models:
Some applications of in vitro human cell models:
- Discovery of novel drug targets
- Identification of disease related lesions and underlying molecular mechanisms in asthma and COPD
- Proof of concept testing and validation of novel drug targets
- Screening assays for novel drug targets and lead target selection
- Generation of samples for proteomic and genomic analytical techniques
- Support for clinical trial activities
Bronchial epithelial cells differentiated in vitro
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A) Transmission electron microscopy on a vertical section through epithelial culture showing a basal cell (b) layer with overlying ciliated cells (c) and
goblet cells (g)
B) Confocal microscopy showing ciliated cells (green) and mucus-producing goblet cells (blue) and cell nuclei counterstained in red |
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