Developing advanced human tissue models of
respiratory disease
Compared to progress in other disease areas, there have been relatively few advances in the treatment of the major respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD). Research has been hampered by the inability of animal models to replicate truly disease pathology and chronicity, as well as the impact of environmental factors in asthma and COPD.  As such, animal models have not always been predictive of efficacy in chronic respiratory diseases.

To avoid such issues and to accelerate target discovery Synairgen has focussed on advanced cell models using tissue and cells from human subjects.  Synairgen has developed a Biobank of clinical samples obtained from well-characterised healthy control, asthma or COPD volunteers.

The Biobank samples obtained from these clinically well-characterised
volunteers include:

• Blood
• Sputum
• Biopsies (fresh and resin embedded)
• Bronchial fibroblast cells
• Bronchial epithelial cells